重组人血红素加氧酶1(HO-1)(HMOX1)(HSP32)

中文名称：重组人血红素加氧酶1(HO-1)(HMOX1)(HSP32)
英文名称：Recombinant Human Heme Oxygenase 1
产品规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Thr261表达纯化得来。

HO-1/HMOX1/HSP32质量控制：＞95%(还原性SDS-PAGE)

HO-1/HMOX1/HSP32制剂：液体

HO-1/HMOX1/HSP32保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于HO-1/HMOX1/HSP32：
Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. 

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