Recombinant Murine Midkine
Catalog Number:
315-25
Synonyms:
MK, NEGF-2
Description:
Midkine and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis. Recombinant murine Midkine is a 13.4 kDa protein containing 121 amino acid residues including five intra-molecular disulfide bonds.
AA Sequence:
MVAKKKEKVK KGSECSEWTW GPCTPSSKDC GMGFREGTCG AQTQRVHCKV PCNWKKEFGA DCKYKFESWG ACDGSTGTKA RQGTLKKARY NAQCQETIRV TKPCTSKTKS KTKAKKGKGK D
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/ml.
 
 
 
 
Research Interests:


    

        

            

            
Angiogenesis/ Cardiovascular
            

            
Neurobiology
        
    


 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.