PRF1 (Human) Recombinant Protein (P01)
产品名称: PRF1 (Human) Recombinant Protein (P01)
英文名称: PRF1 (Human) Recombinant Protein (P01)
产品编号: H00005551-P01
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Human PRF1 full-length ORF ( AAH63043.1, 22 a.a. - 555 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- PCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFLGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
- Theoretical MW (kDa):
- 84.48
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
- Download
- Publication Reference
- 1.
- Role of the inflammatory protein serine protease inhibitor Kazal in preventing cytolytic granule granzyme A-mediated apoptosis.
Lu F, Lamontagne J, Sun A, Pinkerton M, Block T, Lu X.Immunology. 2011 Dec;134(4):398-408. doi: 10.1111/j.1365-2567.2011.03498.x.
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 5551
- GeneBank Accession#:
- BC063043
- Protein Accession#:
- AAH63043.1
- Gene Name:
- PRF1
- Gene Alias:
- FLH2,HPLH2,MGC65093,P1,PFN1,PFP
- Gene Description:
- perforin 1 (pore forming protein)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
- Other Designations:
- OTTHUMP00000019759,cytolysin,lymphocyte pore forming protein,perforin 1
- Related Disease
- Alzheimer Disease
- Arthritis, Juvenile Rheumatoid
- Asthma
- Asthma
- Autoimmune Diseases
- Bronchiolitis, Viral
- Diabetes Mellitus, Type 1
- Disease Progression
- Epstein-Barr Virus Infections
- Genetic Predisposition to Disease
- HIV Infections
- HTLV-I Infections
- Infant, Premature, Diseases
- Leukemia, B-Cell, Acute
- Leukemia, Lymphocytic, Acute, L1
- Lymphohistiocytosis, Hemophagocytic
- Lymphoma, Large-Cell, Ki-1
- Lymphoproliferative Disorders
- Macrophage Activation Syndrome