PTPRC monoclonal antibody, clone UCHL1
产品名称： PTPRC monoclonal antibody, clone UCHL1
英文名称： PTPRC monoclonal antibody, clone UCHL1
产品编号： MAB3873
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
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- Specification
- Product Description:
- Mouse monoclonal antibody raised against native PTPRC.
- Immunogen:
- Native purified PTPRC from human IL-2 dependent T cells.
- Host:
- Mouse
- Theoretical MW (kDa):
- 180
- Reactivity:
- Human
- Specificity:
- This antibody recognizes CD45R0, a 180 KDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes.
- Form:
- Liquid
- Purification:
- Protein G purification
- Concentration:
- 1 mg/mL
- Isotype:
- IgG2a
- Storage Buffer:
- In PBS, pH 7.4 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Phenotypic diversity of the CD45 antigen and its relationship to function.
Beverley PC, Merkenschlager M, Terry L.Immunol Suppl. 1988;1:3-5.
- 2.
- Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation.
Merkenschlager M, Terry L, Edwards R, Beverley PC.Eur J Immunol. 1988 Nov;18(11):1653-61.
- 3.
- The monoclonal antibody, UCHL1, recognizes a 180,000 MW component of the human leucocyte-common antigen, CD45.
Terry LA, Brown MH, Beverley PC.Immunology. 1988 Jun;64(2):331-6.
- Application Image
- Immunohistochemistry
- Immunoprecipitation
- Flow Cytometry
- Entrez GeneID:
- 5788
- Gene Name:
- PTPRC
- Gene Alias:
- B220,CD45,CD45R,GP180,LCA,LY5,T200
- Gene Description:
- protein tyrosine phosphatase, receptor type, C
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
- Other Designations:
- CD45 antigen,T200 glycoprotein,T200 leukocyte common antigen,glycoprotein,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptide
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