IR VIVO近红外二区小动物活体成像系统
产品名称： IR VIVO近红外二区小动物活体成像系统
英文名称：
产品编号： IR VIVO
产品价格： 0
产品产地： 加拿大
品牌商标： PHOTON ETC
更新时间： null
使用范围： null
上海佰珐科学仪器有限公司
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- 地址 : 上海市徐汇区
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- 所在区域 : 上海
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- 邮箱 : yolanda@biotimestech.com
IR VIVOTM 近红外二区小动物活体成像系统
目前常见的分子影像技术如X-射线成像、断层扫描成像（CT）、磁共振成像（MRI）和超声成像（US）被用于对疾病等的医疗诊断，但这些方法具有较差的空间分辨率及其无法实现动态实时监测等缺点。光学成像技术以其高灵敏度和高时空分辨率等优点，为微小肿瘤/转移瘤及肿瘤相关血管的检测和研究提供了一种新的无创检测成像手段，在生物医学和临床诊断中发挥着重要作用。在过去几年里，研究者们致力于研究近红外第一窗口（700 nm~900 nm）的荧光成像，但是由于生物组织在这个波段范围内有很强的吸收和散射，致使其信噪比和组织穿透深度都比较低。相对于NIR-I区成像，新一代的近红外二区光学成像（NIR-II，1000-1700 nm）在成像灵敏度、穿透深度和空间分辨率方面有着显著提高。因此，近年来，位于近红外第二窗口（NIR-II，1000 nm~1700 nm）的材料得到了广泛的关注，在这个波段，生物组织自身的吸收和散射弱，这样就可以极大地提高成像质量和穿透深度。目前，一些无机材料如稀土下转换纳米颗粒、碳纳米管、量子点以及少数有机染料能够实现NIR-II的发射，但是它们的激发波长都位于近红外第一窗口内。因此，开发激发波长和发射波长都位于NIR-II的材料成为目前生物成像的热点。
IR-VIVO是一款用于用于活体近红外二区成像的高光谱成像系统。IR-VIVO使用可调谐滤波片和高光谱提供多光谱成像，成像范围可从850nm到1620nm，分辨率可达到4nm，凭借高效率的滤波器和高速科研级SWIR相机，VIVO可以准确的获得多个IR荧光谱，并可以实时成像，为涉及第二生物窗口检测的应用提供了完美工具。近红外二区（1000至1700 nm）中成像时，组织的散射减少，组织吸收和自发荧光最小。结果，与传统的可见光或红外光学成像（即400-1000 nm）相比，在这些波长下具有更好的图像对比度，灵敏度和对组织的穿透深度。
NIR-II成像特性
- 高空间分辨率
- 高时间分辨率（实时动态）
- 非电离和非侵入性
- 良好的穿透深度（比传统的可见光学系统大10倍）
应用领域：
NIR-II成像增加的穿透深度和对比度，再加上快速的采集速度和微米级的空间分辨率，可以同时观察通过完整颅骨的微脉管系统和血流。其他生物学应用包括化疗药物的药代动力学以及肝脏和血液循环中的脂质定量。
PHOTON ETC还开发了临床前的二区成像红外相机ZephIR™1.7，以满足研究二区生物学窗口的研究人员的需求。
PUBLICATIONS
1.REAL TIME IN VIVO IMAGING IF ICG IN THE NIR-II
with IR VIVO™ Imaging system
We sought to develop a near infrared II small animal imaging system which could provide real time images and videos of shortwave IR (SWIR) fluorescent signals in vivo at wavelengths over 1000 nm. It was hypothesized that the SWIR wavelengths would give optimal resolution for in vivo optical imaging due to the low tissue autofluorescence, scattering and absorption of light at these wavelengths. The desired preclinical imaging system should enable measurement of heart rate, respiratory rate, hepatic function, hepatobiliary and intestinal function, blood flow and angiography in small animals.
2.INSIGHT FROM THE INDUSTRY - IR VIVO
USING PRE-CLINICAL IMAGING TO DETECT CANCER
By émilie Beaulieu-Ouellet, Application Scientist in Life Science
In this interview, émilie Beaulieu Ouellet talks about the recently released and breakthrough imaging system: the IR VIVO™ and its technology. Photon etc.’s IR VIVO™ system is the first and only turnkey hyperspectral preclinical imager optimized for imaging in the second biological window of the near-infrared (NIR-II) / short-wavelength infrared (SWIR) range available on the market to our knowledge. NIR-II imaging will bring an unprecedented combination of fast, high resolution and penetration depth imaging at lower cost and to a broader community than current preclinical imaging techniques. Altogether, it will enable to resolve and track single biomedical targets or processes throughout small animals, thereby opening a new window of possibilities for fundamental and biopharmaceutical research.
1.REAL TIME IN VIVO IMAGING IF ICG IN THE NIR-II
with IR VIVO™ Imaging system
We sought to develop a near infrared II small animal imaging system which could provide real time images and videos of shortwave IR (SWIR) fluorescent signals in vivo at wavelengths over 1000 nm. It was hypothesized that the SWIR wavelengths would give optimal resolution for in vivo optical imaging due to the low tissue autofluorescence, scattering and absorption of light at these wavelengths. The desired preclinical imaging system should enable measurement of heart rate, respiratory rate, hepatic function, hepatobiliary and intestinal function, blood flow and angiography in small animals.
2.INSIGHT FROM THE INDUSTRY - IR VIVO
USING PRE-CLINICAL IMAGING TO DETECT CANCER
By émilie Beaulieu-Ouellet, Application Scientist in Life Science
In this interview, émilie Beaulieu Ouellet talks about the recently released and breakthrough imaging system: the IR VIVO™ and its technology. Photon etc.’s IR VIVO™ system is the first and only turnkey hyperspectral preclinical imager optimized for imaging in the second biological window of the near-infrared (NIR-II) / short-wavelength infrared (SWIR) range available on the market to our knowledge. NIR-II imaging will bring an unprecedented combination of fast, high resolution and penetration depth imaging at lower cost and to a broader community than current preclinical imaging techniques. Altogether, it will enable to resolve and track single biomedical targets or processes throughout small animals, thereby opening a new window of possibilities for fundamental and biopharmaceutical research.