ANTXR1 polyclonal antibody
产品名称： ANTXR1 polyclonal antibody
英文名称： ANTXR1 polyclonal antibody
产品编号： PAB13110
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ANTXR1.
- Immunogen:
- A synthetic peptide corresponding to C-terminus13 amino acids of human ANTXR1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- ATR will recognize only the largest isoform.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of the cellular receptor for anthrax toxin.
Bradley KA, Mogridge J, Mourez M, Collier RJ, Young JA.Nature. 2001 Nov 8;414(6860):225-9.
- 2.
- Cell surface tumor endothelial markers are conserved in mice and humans.
Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B.Cancer Res. 2001 Sep 15;61(18):6649-55.
- 3.
- Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.
Duesbery NS, Webb CP, Leppla SH, Gordon VM, Klimpel KR, Copeland TD, Ahn NG, Oskarsson MK, Fukasawa K, Paull KD, Vande Woude GF.Science. 1998 May 1;280(5364):734-7.
- Entrez GeneID:
- 84168
- Protein Accession#:
- NP_444262
- Gene Name:
- ANTXR1
- Gene Alias:
- ATR,FLJ10601,FLJ11298,FLJ21776,TEM8
- Gene Description:
- anthrax toxin receptor 1
- Omim ID:
- 606410
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq
- Other Designations:
- 2310008J16Rik,2810405N18Rik,tumor endothelial marker 8