SECISBP2抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
SECISBP2抗体

SECISBP2抗体

商家询价

产品名称： SECISBP2抗体

英文名称： SECISBP2Antibody

产品编号： XY12798-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 SECISBP2抗体Applications

In-house applications ELISA, WB, IP, IF     Application not tested? Please see our Guarantee.
Published applications IF, WB Publications 2 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 12798-1-AP;HeLa cellsHeLa cells were subjected to SDS PAGE followed by western blot with 12798-1-AP(SECISBP2 antibody) at dilution of 1:400
  • 12798-1-AP;mouse testis tissueIP Result of anti-SECISBP2 (IP:12798-1-AP, 3ug; Detection:12798-1-AP 1:600) with mouse testis tissue lysate 8000ug.
  • 12798-1-AP;HeLa cellsImmunofluorescent analysis of HeLa cells using 12798-1-AP( SECISBP2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in HeLa cells, human kidney tissue, Jurkat cells
Positive IP detected in Mouse testis tissue
Positive IF detected in HeLa cells
Recommended dilution WB : 1:500-1:5000
IP : 1:200-1:2000
IF : 1:20-1:200
 SECISBP2抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information SECISBP2抗体
Immunogen SECISBP2 fusion protein ag3541 Full name SECIS binding protein 2
Calculated molecular
weight		 854aa,95 kDa Observed molecular 
weight		 95 kDa
GenBank accession 
number		 BC036109 Gene ID (NCBI) 79048
Gene symbol SECISBP2 Synonyms DKFZp686C09169, SBP2, SECIS binding protein 2, SECISBP2
Background

Selenium (Se) is an essential trace element required for the biosynthesis of selenoproteins, and selenocysteine insertion sequence (SECIS) binding protein 2 (SECISBP2, or SBP2) represents a key trans-acting factor for the cotranslational insertion of selenocysteine into selenoproteins. Defects in SBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM) associated with a reduction in type II iodothyronine deiodinase activity. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Cells depleted of SBP2 have increased levels of ROS, which lead to cellular oxidative stress manifested as DNA lesions, stress granules, and lipid peroxidation, induction of caspase- and cytochrome c-dependent apoptosis, indicating that SBP2 is required for protection against ROS-induced cellular damage and cell survival. SECISBP2抗体

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