ECGenieTM是世界上唯一无创的、可测量处于清醒状态的小动物（小鼠、大鼠和豚鼠）心电图测试系统。

*既可测量新生鼠也可测量成年鼠。 
*动物不需固定，不需麻醉，不需手术。 
*操作简便易行，实验人员只需简单的将动物放置在记录平台上即可。 
*每小时可检测10只动物，效率大大提高。 
*高通滤波和低通滤波

应用： 
Phenotyping 表型 
Genotyping 基因类型 
Health Monitoring 健康监控 
Neonatal Electrocardiograms 新生动物心电图 
Arrhythmias 心律失常 
Cardiac hypertrophy 心脏肥大 
Cardiovascular studies 心血管研究 
CNS studies 中枢神经系统的研究 
Developmental studies 发展研究 
Endocrine studies 内分泌研究 
Metabolic studies 代谢研究 
Preclinical study of new compounds 新化合物的临床前研究 

参数： 
Heart rate 心率 
Heart rate variability心率变异性 
RR interval RR间期 
PR interval PR间期 
QRS interval QRS间期 
QT and QTc intervals QT和QTc间期

应用ECGenieTM小动物心电图测试系统所发表的论文，已经在多达15种刊物上发表。具体如下： 
ECGenieTM ECG Screening system for non-invasively recording ECGs in conscious mice. 

1. Shioi T, Hampton TG, Douglas P, and Izumo S. Dominant negative p21ras 
causes a progressive dilated cardiomyopathy in transgenic mice. Circulation, 1999; 100(18);I-52. 

2. Amende I, Chu V, Morgan JP, and Hampton TG. Angiotensin II AT1 receptor blockade attenuates isoproterenol-induced cardiac hypertrophy in mice. Eur Heart J, 27(Supp.):2161. 2000. 

3. Chu V, Otero JM, Lopez O, Morgan JP, Amende I, Hampton TG. Method for non-invasively recording electrocardiograms in conscious mice. BioMedCentral Physiology 2001, 1(1):6. 

4. Braun A, Trigatti BL, Post MJ, Sato K, Simons M, Edelberg JM, Rosenberg RD, Schrenzel M, Krieger M. Loss of SR-BI Expression Leads to the Early Onset of Occlusive Atherosclerotic Coronary Artery Disease, Spontaneous Myocardial Infarctions, Severe Cardiac Dysfunction, and Premature Death in Apolipoprotein E. Deficient Mice. Circ Res 2002; 90: 270-276. 

5. Chu V, Otero JM, Lopez O, Sullivan M, Morgan JP, Amende I, Hampton TG. 
Electrocardiographic findings in mdx mice: a cardiac phenotype of Duchenne muscular 
dystrophy. Muscle & Nerve 2002;513-519. 

6. Min JY, Sullivan MF, Yan X, Feng X, Chu V, Wang JF, Amende I, Morgan JP, Philipson KD, Hampton TG. Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction. Am J Physiol Heart Circ Physiol 2002 Dec;283(6):H2466-71. 

7. Braun A, Zhang S, Miettinen HE, Ebrahim S, Holm TM, Vasile E, Post MJ, Yoerger DM, Picard MH, Krieger JL, Andrews NC, Simons M, Krieger M. Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein-E double knockout mouse. Proc Nat Acad Sci 2003; 100:7283-7288. 

8. Sutliff RL, Haase C, Russ R, Hoit BD, Morris R, Norman AB, and Lewis W. Cocaine Increases Mortality and Cardiac Mass in a Murine Transgenic Model of Acquired Immune Deficiency Syndrome. Lab Invest ; 2003; 83: 983. 

9. Svenson KL, Bogue MA, Peters LL. Invited review: Identifying new mouse models of 
cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains. J Appl Physiol 2003 94:1650-9. 

10. Amende I, Dubach JM, Piskorski K, Morgan JP, and Hampton TG. ECG Monitoring and Analyses in Mice. The Physiological Genomics of the Critically Ill Mouse in Basic Science for the Cardiologist. 2004 pgs. 89-100. 

11. Bachman E., Hampton TG, Dhillon H, Amende I, Wang J., Morgan JP and Hollenberg AN - The Metabolic and Cardiovascular Effects of Hyperthyroidism are Largely Independent of Beta-Adrenergic StimulationEndocrinology 2004;145:2767-74. 

12. Lewis W, Miller Y, Haase C, Ludaway T, McNaught J, Russ R, Steltzer J, Folpe A, Long R and Oshinski J - HIV viral protein R causes atrial cardiomyocyte mitosis, mesenchymal tumor, dysrhythmia, and heart failure Lab Invest 2005; 85:182-92. 

13. Maddatu TP, Garvey SM, Schroeder DG, Hampton TG, Cox GA. Transgenic rescue of neurogenic atrophy in the nmd mouse reveals a role for Ighmbp2 in dilated cardiomyopathy. Hum Mol Genet. 2004;13:1105-15. 

14. Piskorksi K, Kale A, Chu V, Otero JM, Gladstone K, Mueller P, Amende I, and Hampton TG. Non-invasive physiology in conscious mice. 2002 Fourth World Congress Alternatives Congress Trust Proceedings. 2004, in press. ATLA 32, Supplement 1, 195–201, 2004. 

15. Sanna MG, Liao J, Jo E, Alfonso C, Ahn M, Peterson MS, Webb B, Lefebvre S, Chun J, Gray N, 
Rosen H; Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, 
Regulate Lymphocyte Recirculation and Heart Rate. The Journal of Biological Chemistry 2004; 
279: 13839–13848. 

16. Schuldt AJT, Hampton TG, Chu V, Vogler CA, Galvin N, Lessard ML, Barker JE. Cardiac anomalies in beta-glucuronidase (GUSB) null mice are corrected by non-ablative neonatal marrow transplantation. Proc Nat Acad Sci 2004; 101:603–608. 

17. Sergey V. Ivanov, Jerrold M. Ward, Lino Tessarollo, Dorothea McAreavey, Vandana Sachdev,_ Lameh Fananapazir,_ Melissa K. Banks, Nicole Morris, Draginja Djurickovic, Deborah E. Devor- Henneman, Ming-Hui Wei, Gregory W. Alvord, Boning Gao, James A. Richardson, John D. Minna, Michael A. Rogawski, and Michael I. Lerman?? - Cerebellar Ataxia, Seizures, Premature Death, and Cardiac Abnormalities in Mice with Targeted Disruption of the Cacna2d2 Gene American Journal of Pathology 2004; 165:1007-1018. 

18. Lewis W, Haase CP, Miller YK, Ferguson B, Stuart T, Ludaway T, McNaught J, Russ R, Steltzer J., Santoianni R, Long R, Fiermonte G, Palmieri F. Transgenic expression of the deoxynucleotide 
carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS. Lab Invest. 2005; 85:972-81. 

19. Zhang S, Picard MH, Vasile E, Zhu Y, Raffai RL, Weisgraber KH, Krieger M. 
Diet-induced-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice.Circulation. 2005 111:3457-64. 

20. Cho H, Park C. ,Hwang I, Han S, Schimel D, Despres D. and Kehrl JH 
Rgs5 Targeting Leads to Chronic Low Blood Pressure and a Lean Body Habitus. 
Molecular and Cellular Biology 2008, 28:2590–2597. 

21. Hsiai, TK., Yu, H, Kim, ES, Ai, L 
POLYMER-BASED CARDIOVASCULAR BIOSENSORS, MANUFACTURE, AND 
USES THEREOF United States Patent Application 20080302675 

22. Non-invasively record ECGs in mice. 
Arizona Branch AALAS Newsletter Vol. 22 No. 1 February 2009 p.13 

23. Isenberg JS, Qin Y, Maxhimer JB, Sipes JM, Despres D, Schnermann J, Frazier WA, 
Roberts DD. Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. Matrix Biol. 2009;28:110-9. 

24. Shuqin Xing, Shirng-Wreng Tsaih, Rong Yuan, Karen L. Svenson, Linda M. Jorgenson, Milly So, Beverly J. Paigen, and Ron Korstanje. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol. 2009; 296:H1907-13 

25. Mabe AM and Hoover DB Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice Cardiovascular Research 2009; 82:93–99. 

26. Lachance D, Plante E, Bouchard-Thomassin A, Champetier S, Roussel E, Drolet MC, Couet J and Arsenault M. Moderate Exercise Training Improves Survival and Ventricular Remodeling in an Animal Model of Left Ventricular Volume Overload. Circ Heart Fail. 2009; 5:437-45. 

27. Lynch KR, Macdonald TL 
PHENYL-CYCLOALKYL AND PHENYL-HETEROCYCLIC DERIVATIVES AS S1P 
RECEPTOR AGONISTS United States Patent Application 20090105315 

28. Heier CR, Hampton TG, Wang D, Didonato CJ. 
Development of electrocardiogram intervals during growth of FVB/N neonate mice. 
BMC Physiol. 2010 Aug 24;10:16. 

29. Heier CR, Satta R, Lutz C, Didonato CJ. 
Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice. 
Hum Mol Genet. 2010 Aug 18.