Human Growth Factors & Cytokines
            
Recombinant Human FGF-acidic
            

            

             
        
        

            
 
            

            

                

                    

                        

                        
Synonyms :
                        
                        

                        
Fibroblast Growth Factor-acidic, FGF-1, HBGF-1, ECGF-beta
                        
                    
                    

                        

                        
Description :
                        
                        

                        
FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant human FGF-acidic is a 15.8 kDa protein consisting of 140 amino acid residues.
                        
                    
                    

                        

                        
Catalog #:
                        
                        

                        
100-17A
                        
                    
                    

                        

                        
Source :
                        
                        

                        
E.coli
                        
                    
                    

                        

                        
Purity :
                        
                        

                        
Greater than 95% by SDS-PAGE gel and HPLC analyses.
                        
                    
                    

                        

                        
Endotoxin Level :
                        
                        

                        
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
                        
                    
                    

                        

                        
Biological Activity :
                        
                        

                        
Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg. 

                        

                        Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 0.5 ng/ml in the presence of 10 μg/ml heparin, corresponding to a specific activity of ≥ 2 x 106 units/mg.
                        
                    
                    

                        

                        
Selected References :
                        
                        

                        
Selected List of References Citing This PeproTech Product
                        
                    
                    

                        

                        
AA Sequence :
                        
                        

                        
MFNLPPGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SVGEVYIKST ETGQYLAMDT DGLLYGSQTP NEECLFLERL EENHYNTYIS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D 
                        
                    
                    

                        

                        
PubMed Link :
                        
                        

                        
FGF-1
                        
                    
                    

                        

                        
Country of Origin :
                        
                        

                        
USA
                        
                    
                    

                        
 
                        

                        
                    
                    

                        

                        
 
                        
                        

                        

                        

                            

                                

                                    
Size A
                                    
10μg
                                    
$80 
                                    
 
                                
                                

                                    
 
                                
                                

                                    
Size B
                                    
50μg
                                    
$195 
                                    
 
                                
                                

                                    
 
                                
                                

                                    
Size C
                                    
1mg
                                    
$1500 
                                    
 
                                
                                

                                    
 
                                
                            
                        
                        

                        
                    
                    

                        

                        
 
                        
                        

                        
                    
                    

                        

                        
 
                        
                        

                        
Special Sizes: 

                        Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
                        
                    
                    

                        

                        
 
                        
                        

                        
Usage:

                        For Research Use Only. Not for use in diagnostic or therapeutic procedures.