Anti-DFFB Polyclonal Antibody

商品货号：	商品品牌：	规格	基本售价：	选择规格
K001846P-50ul	solarbio	50ul	960.00元
K001846P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-DFFB Polyclonal Antibody
别名	CAD;CPAN;DFF-40;DFF2;DFF40
应用	WB
稀释比例	WB 1:200-1000.
交叉反应	Human Mouse
蛋白分子量	39kDa
Gene ID	1677
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human DFFB
性状	液体
Public Immunogen Range	Recombinant protein of human DFFB
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	O76075
克隆类型	Polyclonal Antibody
背景资料	Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.