INPP5D monoclonal antibody, clone SHIP-02
产品名称： INPP5D monoclonal antibody, clone SHIP-02
英文名称： INPP5D monoclonal antibody, clone SHIP-02
产品编号： MAB3646
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic peptide of INPP5D.
- Immunogen:
- A synthetic peptide corresponding to N-terminus human INPP5D.
- Host:
- Mouse
- Theoretical MW (kDa):
- 110, 125, 130, 135,
- Reactivity:
- Human
- Specificity:
- This antibody reacts with SHIP-1, a phosphoinositide phosphatase largely confinedto hematopoietic cells. Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 KDa.
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Isotype:
- IgG2a
- Storage Buffer:
- In PBS, pH 7.4 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (2-5 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs.
Rovenska M, Hlouchova K, Sacha P, Mlcochova P, Horak V, Zamecnik J, Barinka C, Konvalinka J.Prostate. 2008 Feb 1;68(2):171-82.
- 2.
- Expression of glutamate carboxypeptidase II in human brain.
Sacha P, Zamecnik J, Barinka C, Hlouchova K, Vicha A, Mlcochova P, Hilgert I, Eckschlager T, Konvalinka J.Neuroscience. 2007 Feb 23;144(4):1361-72. Epub 2006 Dec 5.
- 3.
- Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
Mesters JR, Barinka C, Li W, Tsukamoto T, Majer P, Slusher BS, Konvalinka J, Hilgenfeld R.EMBO J. 2006 Mar 22;25(6):1375-84. Epub 2006 Feb 9.
- Applications
- Western Blot (Cell lysate)
- Western Blotting analysis (reducing conditions) of human INPP5D in whole cell lysate of THP-1 (human acute monocytic leukemia cell line).
Lane 1 : Immunostaining with Isotype mouse IgG1 control.
Lane 2, 3 : Immunostaining with INPP5D monoclonal antibody, clone SHIP-01 (Cat # MAB3645) Lane 4, 5 : Immunostaining with INPP5D monoclonal antibody, clone SHIP-02 (Cat # MAB3646).
- Entrez GeneID:
- 3635
- Gene Name:
- INPP5D
- Gene Alias:
- MGC104855,MGC142140,MGC142142,SHIP,SHIP1,SIP-145,hp51CN
- Gene Description:
- inositol polyphosphate-5-phosphatase, 145kDa
- Omim ID:
- 601582
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
- Other Designations:
- SH2 containing inositol phosphatase,SH2 containing inositol phosphatase, isoform b,p150Ship,signaling inositol polyphosphate 5 phosphatase SIP-145