TIRAP polyclonal antibody
产品名称: TIRAP polyclonal antibody
英文名称: TIRAP polyclonal antibody
产品编号: PAB6892
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of TIRAP.
- Immunogen:
- A synthetic peptide corresponding to human TIRAP.
- Sequence:
- C-QTLLKKPKKRPNSPE
- Host:
- Goat
- Theoretical MW (kDa):
- 23.9, 24.8
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize both reported isoforms (NP_001034750.1 and NP_683708.1).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Preferential expression and function of Toll-like receptor 3 in human astrocytes.
Farina C, Krumbholz M, Giese T, Hartmann G, Aloisi F, Meinl E.J Neuroimmunol. 2005 Feb;159(1-2):12-9. Epub 2004 Nov 11.
- Entrez GeneID:
- 114609
- Protein Accession#:
- NP_001034750.1;NP_683708.1
- Gene Name:
- TIRAP
- Gene Alias:
- FLJ42305,Mal,wyatt
- Gene Description:
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
- Other Designations:
- MyD88 adapter-like protein,OTTHUMP00000179130,OTTHUMP00000179132,TIR domain-containing adapter protein,TIR domain-containing adaptor protein,Toll-interleukin 1 receptor (TIR) domain-containing adapter protein,Toll-interleukin 1 receptor (TIR) domain-conta
- Gene Pathway
- Related Disease
- Acute Lung Injury
- Bacteriuria
- Candidiasis, Oral
- Cardiovascular Diseases
- Chagas Cardiomyopathy
- Chronic Disease
- Cross Infection
- Cystitis
- Dermatitis, Atopic
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Genetic Predisposition to Disease
- HIV Infections
- Inflammation
- Leprosy
- Lupus Erythematosus, Systemic
- Malaria, Falciparum
- Pneumonia, Ventilator-Associated