STAT2 polyclonal antibody
产品名称： STAT2 polyclonal antibody
英文名称： STAT2 polyclonal antibody
产品编号： PAB3578
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of STAT2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human STAT2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation.
Rodriguez JJ, Wang LF, Horvath CM.J Virol. 2003 Nov;77(21):11842-5.
- 2.
- The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signaling.
Gotoh B, Takeuchi K, Komatsu T, Yokoo J.J Virol. 2003 Mar;77(6):3360-70.
- 3.
- Affinity of Stat2 for the subunits of the interferon alpha receptor.
Saleh AZ, Nguyen VP, Krolewski JJ.Biochemistry. 2002 Sep 17;41(37):11261-8.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of K-562 cell lysate (35 ug/lane) with STAT2 polyclonal antibody (Cat # PAB3578).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with STAT2 polyclonal antibody (Cat # PAB3578) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 6773
- Protein Accession#:
- P52630
- Gene Name:
- STAT2
- Gene Alias:
- ISGF-3,MGC59816,P113,STAT113
- Gene Description:
- signal transducer and activator of transcription 2, 113kDa
- Omim ID:
- 600556
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. [provided by RefSeq
- Other Designations:
- interferon alpha induced transcriptional activator,signal transducer and activator of transcription 2
- Related Disease