BMPR1A (N-term) Peptide
产品名称: BMPR1A (N-term) Peptide
英文名称: BMPR1A (N-term) Peptide
产品编号: P0790
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of BMPR1A.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to amino acids 39-69 at N-terminus of human BMPR1A.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels.
Waite KA, Eng C.Hum Mol Genet. 2003 Mar 15;12(6):679-84.
- 2.
- Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.
Zhou XP, Woodford-Richens K, Lehtonen R, Kurose K, Aldred M, Hampel H, Launonen V, Virta S, Pilarski R, Salovaara R, Bodmer WF, Conrad BA, Dunlop M, Hodgson SV, Iwama T, Jarvinen H, Kellokumpu I, Kim JC, Leggett B, Markie D, Mecklin JP, Neale K, Phillips R, Piris J, Rozen P, Houlston RS, Aaltonen LA, Tomlinson IP, Eng C.Am J Hum Genet. 2001 Oct;69(4):704-11. Epub 2001 Aug 30.
- 3.
- Chromosomal localization of three human genes encoding bone morphogenetic protein receptors.
Astrom AK, Jin D, Imamura T, Roijer E, Rosenzweig B, Miyazono K, ten Dijke P, Stenman G.Mamm Genome. 1999 Mar;10(3):299-302.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of BMPR1A polyclonal antibody (Cat # PAB3831) in SAOS-2 cell lysate. BMPR1A (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with BMPR1A polyclonal antibody (Cat # PAB3831) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma
- Entrez GeneID:
- 657
- Protein Accession#:
- NP_004320
- Gene Name:
- BMPR1A
- Gene Alias:
- 10q23del,ACVRLK3,ALK3,CD292
- Gene Description:
- bone morphogenetic protein receptor, type IA
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq
- Other Designations:
- OTTHUMP00000020014,activin A receptor, type II-like kinase 3
- Related Disease
- Adenomatous Polyposis Coli
- Alzheimer Disease
- Anemia, Sickle Cell
- Anemia, sickle cell
- Bacteremia
- Chromosome Deletion
- Cleft Lip
- Cleft Palate
- Colon cancer
- Colonic Neoplasms
- Diabetes Mellitus, Type 2
- Gastrointestinal Neoplasms
- Genetic Predisposition to Disease
- Insulin Resistance
- Intestinal Polyposis
- Intestinal Polyps
- Kidney Failure, Chronic
- Liver Cirrhosis
- Neoplastic Syndromes, Hereditary