CASP9 polyclonal antibody
产品名称： CASP9 polyclonal antibody
英文名称： CASP9 polyclonal antibody
产品编号： PAB13077
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CASP9.
- Immunogen:
- A synthetic peptide corresponding to amino acids 41-56 of human CASP9.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- A 46 KDa band should be detected. It has no cross response to other members in caspase family.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex.
Pan G, O'Rourke K, Dixit VM.J Biol Chem. 1998 Mar 6;273(10):5841-5.
- 2.
- Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X.Cell. 1997 Nov 14;91(4):479-89.
- 3.
- ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM.J Biol Chem. 1996 Jul 12;271(28):16720-4.
- Entrez GeneID:
- 842
- Protein Accession#:
- P55211
- Gene Name:
- CASP9
- Gene Alias:
- APAF-3,APAF3,CASPASE-9c,ICE-LAP6,MCH6
- Gene Description:
- caspase 9, apoptosis-related cysteine peptidase
- Omim ID:
- 602234
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. [provided by RefSeq
- Other Designations:
- ICE-like apoptotic protease 6,OTTHUMP00000002322,OTTHUMP00000002323,OTTHUMP00000044594,apoptotic protease MCH-6,apoptotic protease activating factor 3,caspase 9,caspase 9, apoptosis-related cysteine protease
- Interactome
- Related Disease
- Adenocarcinoma
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Carcinoma, Large Cell
- Carcinoma, Non-Small-Cell Lung
- Cardiovascular Diseases
- Clubfoot
- Colorectal Neoplasms
- Crohn Disease
- Crohn's disease
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Esophageal Neoplasms
- Gastrointestinal Stromal Tumors
- Genetic Predisposition to Disease
- Hematologic Diseases
- Hepatitis, Toxic
- Hodgkin Disease