Fibronectin bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectin is involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in fibronectin are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2), also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.