AIPL1 polyclonal antibody
产品名称： AIPL1 polyclonal antibody
英文名称： AIPL1 polyclonal antibody
产品编号： PAB16583
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of AIPL1.
- Immunogen:
- A synthetic peptide corresponding to C-terminus 17 amino acids of human AIPL1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex.
Hidalgo-de-Quintana J, Evans RJ, Cheetham ME, van der Spuy J.Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2878-87. Epub 2008 Apr 11.
- 2.
- The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1.
Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM.Hum Mol Genet. 2002 Oct 15;11(22):2723-33.
- 3.
- Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis.
Sohocki MM, Bowne SJ, Sullivan LS, Blackshaw S, Cepko CL, Payne AM, Bhattacharya SS, Khaliq S, Qasim Mehdi S, Birch DG, Harrison WR, Elder FF, Heckenlively JR, Daiger SP.Nat Genet. 2000 Jan;24(1):79-83.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of AIPL1 in human brain tissue lysate with AIPL1 polyclonal antibody (Cat # PAB16583) at (A) 1 and (B) 2 ug/mL .
- Entrez GeneID:
- 23746
- Protein Accession#:
- NP_055151
- Gene Name:
- AIPL1
- Gene Alias:
- AIPL2,LCA4
- Gene Description:
- aryl hydrocarbon receptor interacting protein-like 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Leber congenital amaurosis (LCA) accounts for at least 5% of all inherited retinal disease and is the most severe inherited retinopathy with the earliest age of onset. Individuals affected with LCA are diagnosed at birth or in the first few months of life with severely impaired vision or blindness, nystagmus and an abnormal or flat electroretinogram. The photoreceptor/pineal -expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, was mapped within the LCA4 candidate region. The protein contains three tetratricopeptide motifs, consistent with nuclear transport or chaperone activity. AIPL1 mutations may cause approximately 20% of recessive LCA. [provided by RefSeq
- Other Designations:
- -