NBN polyclonal antibody
产品名称： NBN polyclonal antibody
英文名称： NBN polyclonal antibody
产品编号： PAB25488
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of NBN.
- Immunogen:
- A synthetic peptide corresponding to N-terminus of human NBN.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- At least three alternatively spliced transcript isoforms of NIBRIN are known to exist.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-2 ug/mL)
Immunohistochemistry (2.5 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Entrez GeneID:
- 4683
- Protein Accession#:
- NP_002476
- Gene Name:
- NBN
- Gene Alias:
- AT-V1,AT-V2,ATV,FLJ10155,MGC87362,NBS,NBS1,P95
- Gene Description:
- nibrin
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq
- Other Designations:
- Nijmegen breakage syndrome 1 (nibrin),cell cycle regulatory protein p95,p95 protein of the MRE11/RAD50 complex
- Gene Pathway
- Related Disease
- Acute Disease
- Adenocarcinoma
- Astrocytoma
- Ataxia telangiectasia
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Basal Cell
- Carcinoma, Ductal
- Carcinoma, Ductal, Breast
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Transitional Cell
- Central Nervous System Neoplasms
- Chromosomal Instability
- Chromosome Aberrations
- Chromosome Breakage
- Chromosome Deletion
- Cleft Lip
- Cleft Palate