APEX1 polyclonal antibody
产品名称： APEX1 polyclonal antibody
英文名称： APEX1 polyclonal antibody
产品编号： PAB12487
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against recombinant APEX1.
- Immunogen:
- Recombinant protein corresponding to human APEX1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to the human APE/ref-1protein.
- Form:
- Liquid
- Storage Buffer:
- In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
- Storage Instruction:
- Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunoprecipitation (7 ug/mL)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma.
Lam W, Bussom S, Cheng YC.Mol Cancer Ther. 2009 Feb;8(2):415-23. Epub 2009 Feb 10.
- 2.
- Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.
Raffoul JJ, Banerjee S, Singh-Gupta V, Knoll ZE, Fite A, Zhang H, Abrams J, Sarkar FH, Hillman GG.Cancer Res. 2007 Mar 1;67(5):2141-9.
- 3.
- Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA.
Yang B, Chen K, Zhang C, Huang S, Zhang H.J Biol Chem. 2007 Apr 20;282(16):11667-75. Epub 2007 Feb 1.
- 4.
- Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.
Briegert M, Kaina B.Cancer Res. 2007 Jan 1;67(1):26-31.
- 5.
- Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis.
Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DP, Lin PC.Cancer Cell. 2004 Oct;6(4):409-21.
- Application Image
- Western Blot (Cell lysate)
- enlarge
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- Immunocytochemistry
- Immunofluorescence
- Immunoprecipitation
- Entrez GeneID:
- 328
- Protein Accession#:
- P27695
- Gene Name:
- APEX1
- Gene Alias:
- APE,APE-1,APE1,APEN,APEX,APX,HAP1,REF-1,REF1
- Gene Description:
- APEX nuclease (multifunctional DNA repair enzyme) 1
- Omim ID:
- 107748
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq
- Other Designations:
- AP endonuclease class I,AP lyase,APEX nuclease,DNA-(apurinic or apyrimidinic site) lyase,OTTHUMP00000163988,apurinic/apyrimidinic (abasic) endonuclease,apurinic/apyrimidinic exonuclease,deoxyribonuclease (apurinic or apyrimidinic),multifunctional DNA repa
- Gene Pathway
- Related Disease
- Acute Disease
- Adenocarcinoma
- Adenomatous Polyposis Coli
- Adenomyoma
- Alzheimer Disease
- Alzheimer disease
- Amyotrophic Lateral Sclerosis
- Amyotrophic lateral sclerosis
- Anoxia
- Arsenic Poisoning
- Ataxia telangiectasia
- Biliary Tract Neoplasms
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Pancreatic Ductal
- Carcinoma, Squamous Cell
- Carcinoma, Transitional Cell