Animal Free Cytokines
            
Recombinant Rat Thrombopoeitin (TPO)
            

            

             
        
        

            
 
            

            

                

                    

                        

                        
Synonyms :
                        
                        

                        
Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
                        
                    
                    

                        

                        
Description :
                        
                        

                        
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein. Manufactured using all non-animal reagents.
                        
                    
                    

                        

                        
Catalog #:
                        
                        

                        
AF-400-34
                        
                    
                    

                        

                        
Source :
                        
                        

                        
E.coli
                        
                    
                    

                        

                        
Purity :
                        
                        

                        
Greater than 98% by SDS-PAGE gel and HPLC analyses.
                        
                    
                    

                        

                        
Endotoxin Level :
                        
                        

                        
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
                        
                    
                    

                        

                        
Biological Activity :
                        
                        

                        
The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
                        
                    
                    

                        

                        
AA Sequence :
                        
                        

                        
SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRGKVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF 
                        
                    
                    

                        

                        
PubMed Link :
                        
                        

                        
TPO+AND+rat
                        
                    
                    

                        

                        
Country of Origin :
                        
                        

                        
USA
                        
                    
                    

                        
 
                        

                        
                    
                    

                        

                        
 
                        
                        

                        

                        

                            

                                

                                    
Size B
                                    
10μg
                                    
$215 
                                    
 
                                
                                

                                    
 
                                
                                

                                    
Size C
                                    
1mg
                                    
$4700 
                                    
 
                                
                                

                                    
 
                                
                            
                        
                        

                        
                    
                    

                        

                        
 
                        
                        

                        
                    
                    

                        

                        
 
                        
                        

                        
Special Sizes: 

                        Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
                        
                    
                    

                        

                        
 
                        
                        

                        
Usage:

                        For Research Use Only. Not for use in diagnostic or therapeutic procedures.