PeproTech重组人IL-12 2ug-细胞/细菌培养-试剂-生物在线
美国PeproTech(派普泰克)公司中国代表处
PeproTech重组人IL-12 2ug

PeproTech重组人IL-12 2ug

商家询价

产品名称: PeproTech重组人IL-12 2ug

英文名称: Recombinant Human IL-12

产品编号: 200-12H

产品价格: 0

产品产地: 美国

品牌商标: PeproTech

更新时间: null

使用范围: null

美国PeproTech(派普泰克)公司中国代表处
  • 联系人 :
  • 地址 :  江苏省苏州市工业园区星湖街218号A1北座4楼L03
  • 邮编 : 215123
  • 所在区域 : 江苏
  • 电话 : 点击查看
  • 传真 : 点击查看
  • 邮箱 : peprotech.infochina@thermofisher.com

 

Recombinant Human IL-12

Catalog Number:
200-12H
Synonyms:
Interleukin-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF,p35: Interleukin-12 subunit alpha, IL-12 subunit p35, IL-12A, Cytotoxic Lymphocyte Maturation Factor 35 kDa subunit (CLMF p35), NK cell Stimulating Factor Chain 1, p40: Interleukin-12 subunit beta, IL-12 subunit p40, IL-12B, CytotoxicLymphocyte Maturation Factor 40 kDa subunit (CLMF p40), NK cell Stimulating Factor Chain 2
Description:
IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-γ-producing Th1 cells. PeproTechs Recombinant Human IL-12 p70, derived from HEK293 cells, is a heterodimeric glycoprotein consisting of disulfide-linked p35 and p40 subunits (503 total amino acid residues). The calculated molecular weight of Human IL-12 p70 is 57.2 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of 65-70 kDa based on SDS-PAGE gel, under non-reducing conditions.
AA Sequence:


p35 Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS


p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS

Source:
HEK293 cells
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to increase IFN-γ production by anti-TCR mAb-stimulated PBMCs.
 
 
 
 
Research Interests:
Angiogenesis/ Cardiovascular Angiogenesis/ Cardiovascular Cancer Cancer
Immune System Immune System Inflammation Inflammation
Stem Cells & Differentiation Stem Cells & Differentiation Allergy Allergy
Transplantation Transplantation  
 
 
Country of Origin:
USA